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This pass of black and white in 'Overlay' blending mode add auto highlight and shadows to every zones. It's not looking good as it is, but it's a time saver if later you want to rearange them with painting and color-picker.
My final result is the picture under. If you look closely, you can still see all the layers. The main manual pass of details I added are 'specular' points. ( white dot for the reflection of the light ). This technique permited me to do an episode 12 with this pile of potion moving, twisting acting like a character in it's full deconstruction, panel after panel.
This technique could be also used to paint thousands of birds, cars in a street, crowds , etc. I hope reading the part 1 and part 2 will give you more tools and confidence to start painting with 'thousands of things' and not fearing to spend full weeks painting a single panel. Because yes: without this set of techniques I would probably still be detailing episode 12 right now.